HCID 20334287, compound → HCID 59554839, compound

HRID 1888328Notes

Reaction equation

HRID 1888328 reaction equation
O[CH2:2][C@H:3]1[CH2:7][CH2:6][C:5](=[O:8])[N:4]1[CH2:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][CH2:16][C:17]([O:19]CCCC)=[O:18])[N:14]=1.[F:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]1([C:33](=[O:41])[CH2:34]P(=O)(OC)OC)[CH2:32][CH2:31][CH2:30]1>>[F:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]1([C@H:33]([OH:41])/[CH:34]=[CH:2]/[C@H:3]2[CH2:7][CH2:6][C:5](=[O:8])[N:4]2[CH2:9][C:10]2[S:11][CH:12]=[C:13]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])[N:14]=2)[CH2:30][CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 20334287HCID 20334287, compoundHCID 66858297HCID 66858297, compound

Product 1

HCID 59554839HCID 59554839, compound

Procedure

By the same procedure as a series of reactions of Example 5→Example 6→Example 7→Example 8 using the compound 75 instead of the compound 4 and using dimethyl {2-[1-(4-fluorobutyl)cyclobutyl]-2-oxoethyl}phosphonate instead of dimethyl (3,3-dimethyl-2-oxoheptyl)phosphonate, the title compound having the following physical data was obtained.

Sources & evidence

ORD record
ord-5b01d749327d486293be524a40a6ea18
Source dataset
uspto-grants-2013_08
Patent number
US08501793B2

Reaction notes

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