Lithium Hydroxide → HCID 68956958, compound

Participants

Reaction Steps

1 M LiOH (34 ml) was added to a solution of 2-cyano-5-[(S)-3-(4-cyano-3-fluorophenoxy)-2-hydroxy-2-methylpropionylamino]benzoic acid methyl ester (4.52 g, 11.4 mmol) in THF (50 ml) and methanol (6 ml) at 16-18° C. The resulting solution was stirred at room temperature for 2.5 h. The solvents were evaporated and pH was adjusted to 2 with HCl solution. The product was extracted into ethyl acetate. The organic phase was washed with water, dried over Na2SO4 and evaporated. The residue was purified by flash chromatography (eluent: CH2Cl2/MeOH 98:2). Trituration in hot CH2Cl2, cooling to room temperature and filtration yielded the title compound.

Provenance & Evidence