Trifluoroacetic acid → HCID 67203172, compound

Participants

Reaction Steps

A solution of 4-(9-benzenesulfonyl-6-cyano-9H-dipyrido[2,3-b;4′,3′-d]pyrrol-5-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester (202 mg, 0.38 mmol) in dichloromethane (6 mL) was treated with trifluoroacetic acid (2 mL) and the resultant mixture stirred for 1 h then concentrated in vacuo. The residue was purified by flash chromatography (silica, 5 g column, SPE-NH2, 0-8% methanol in DCM) to give title compound as an off white solid (150 mg, 80%). LCMS (Method G): RT=3.07 min, M+H+=432.

Provenance & Evidence