HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Chloro-2-(2,2,2-trifluoroethoxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Benzoic acid, 5-chloro-2-hydroxy-, methyl ester | HCID 77684 | — |
| Reactant | 2,2,2-Trifluoroethyl trifluoromethanesulfonate | HCID 80366 | — |
| Product | 5-Chloro-2-(2,2,2-trifluoroethoxy)benzoic acid | HCID 43141863 | — |
Reaction Steps
Commercially available, methyl 5-chloro-2-hydroxybenzoate (Maybridge), potassium carbonate, 2,2,2-trifluoroethyl trifluoromethanesulfonate (TCI) and sodium hydroxide were processed according to the method of Example 130A to obtain the title compound. MS (ESI+) m/z 253 (M−H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501794B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-200eaa0c4db94518b4754fb0fc59ed3e |
| Source note | uspto-grants-2013_08 |