HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 178441303, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acid | HCID 21491 | — |
| Reactant | 2-tert-Butyl-4-butylisothiazol-5(2H)-imine | HCID 66867228 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178441303 | HCID 178441303 | — |
Reaction Steps
The product from Example 92B and the (+) camphoric acid (Aldrich) were processed using the method described in Example 170 except that the methanol used to trap the intermediate was saturated with ammonia solution instead of methanol to afford the title compound. 1H NMR (DMSO-d6) δ 0.50 (s, 3H), 0.90 (t, J=7.2 Hz, 3H), 1.19 (s, 3H), 1.23-1.44 (m, 3H), 1.26 (s, 3H), 1.57 (s, 9H), 1.57-1.71 (m, 3H), 1.93-2.06 (m, 1H), 2.71-2.82 (m, 1H), 2.62-2.69 (m, 3H), 7.01 (s, 1H), 6.75 (s, 1H), 8.50 (s, 1H). MS (ESI+) m/z 394 (M+H)+. Anal. calcd. for C11H35N3O2S: C, 64.08; H, 8.96; N, 10.68. Found: C, 64.26; H, 9.10; N, 10.65.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501794B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-a7405d8924b6428ca7d618916c83d8e4 |
| Source note | uspto-grants-2013_08 |