Water → HCID 58047154, compound

Participants

Reaction Steps

To a solution of 1-[6-(benzyloxy)-1-benzofuran-2-yl]ethanone (25.7 g, 96.6 mmol) in methanol (300 mL) was added sodium borohydride (3.67 g, 96.6 mmol) by small portions, and the mixture was stirred at room temperature for 1 hr. Water was added to the reaction mixture, and the solvent was evaporated. Ethyl acetate was added thereto, and the mixture was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate=5:1) to give the title compound (18.3 g, yield 71%).

Provenance & Evidence