Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 1-(5-{[Tert-butyl(dimethyl)silyl]oxy}-1-benzofuran-2-yl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | 1-(5-Hydroxy-1-benzofuran-2-yl)ethanone | HCID 3237877 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(5-{[Tert-butyl(dimethyl)silyl]oxy}-1-benzofuran-2-yl)ethanone | HCID 58047498 | 98% |
반응 단계
Using 1-(5-hydroxy-1-benzofuran-2-yl)ethanone (1.15 g, 6.53 mmol), DMF (10 mL), tert-butyldimethylchlorosilane (1.07 g, 7.18 mmol) and imidazole (666 mg, 9.80 mmol), an operation in the same manner as in Reference Example 16 was performed to give the title compound (1.76 g, yield 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08501804B2 |
| 출처 데이터셋 | uspto-grants-2013_08 |
| ORD ID | ord-a4c90fe9f12449ae9ac57b8666de2454 |
| 출처 메모 | uspto-grants-2013_08 |