Dimethyl Sulfoxide → HCID 58047164, compound

Participants

Reaction Steps

To a solution of ethyl mercaptoacetateester (0.450 mL, 4.07 mmol) in DMSO (10 mL) was added sodium hydride (60%, 196 mg, 4.89 mmol) and the mixture was stirred at room temperature for 10 min. To this reaction mixture was added 4-[2-(4-ethoxyphenyl)ethyl]-2-fluorobenzaldehyde (886 mg, 3.26 mmol) obtained in Reference Example 171, and the mixture was stirred at room temperature for 20 min. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed twice with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by basic silica gel column chromatography (hexane:ethyl acetate=19:1 to 1:1) to give the title compound (723 mg, yield 63%) as an oil.

Provenance & Evidence