Isobutyl chloroformate → HCID 67015738, compound

Participants

Role	Name	HCID	Charge
Reactant	Isobutyl chloroformate	HCID 62365	—
Reactant	2-N-Boc-aminopropionic acid	HCID 268471	—
Reactant	Benzoic acid, 4-amino-3-hydroxy-, methyl ester	HCID 7020619	—
Product	HCID 67015738	HCID 67015738	48%

Reaction Steps

Using N-(tert-butoxycarbonyl)-D,L-alanine (3.74 g, 19.7 mmol), 2-methylpropyl chlorocarbonate (2.56 mL, 19.7 mmol) and methyl 4-amino-3-hydroxybenzoate (3.00 g, 19.7 mmol), a method in the same manner as in Reference Example 105 was performed, and the obtained residue was triturated with ethyl acetate to give the title compound (2.94 g, yield 48%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08501804B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-31c11d57abc94c4eb802a22859b926f8
Source note	uspto-grants-2013_08