N-Iodosuccinimide → HCID 178517595, compound

HRID 1888744Notes

Reaction equation

HRID 1888744 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:8])=[N:6][CH:7]=1.[I:9]N1C(=O)CCC1=O>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]([I:9])[C:5]([OH:8])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 178515818HCID 178515818, compound

Product 1

HCID 178517595HCID 178517595, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 5-bromopyridin-2-ol (5.22 g, 30.0 mmol) and N-iodosuccinimide (7.42 g, 33.0 mmol) in acetonitrile (150 mL) was heated under reflux under a nitrogen atmosphere for 1 hr. After being allowed to cool to room temperature, the resulting solid was collected and washed with acetonitrile to give the title compound (7.07 g, yield 79%).

Workup

  1. temperatureunder reflux under a nitrogen atmosphere for 1 hr
  2. customthe resulting solid was collected
  3. washwashed with acetonitrile

Sources & evidence

ORD record
ord-8bbfbd91e2f447c4bdecc17139f3fa6a
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

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