Methanol → Methyl 2-fluoro-4-hydroxybenzoate

Participants

Reaction Conditions

Reaction Steps

A solution of 2-fluoro-4-hydroxybenzoic acid (50.0 g, 294 mmol) and conc. sulfuric acid (10 mL) in methanol (700 mL) was stirred under heating at 90° C. for 16 hr. The reaction solution was concentrated, and the resulting colorless crystals were washed with water and dried to give the title compound (51 g, yield 94%) as colorless crystals.

Provenance & Evidence