HCID 14771605, compound → HCID 58047229, compound

HRID 1888778Notes

Reaction equation

HRID 1888778 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:24]=[CH:23][C:13]3[CH:14]=[C:15]([CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])[O:16][C:12]=3[CH:11]=2)=[CH:4][CH:3]=1.Br[CH2:26][O:27][CH2:28][CH2:29][CH3:30]>>[CH3:26][O:27][CH2:28][CH2:29][CH2:30][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]2[CH:24]=[CH:23][C:13]3[CH:14]=[C:15]([CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])[O:16][C:12]=3[CH:11]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14771605HCID 14771605, compoundHCID 58047041HCID 58047041, compound

Product 1

HCID 58047229HCID 58047229, compoundYield 27%

Procedure

Using N-(1-{6-[2-(4-hydroxyphenyl)ethyl]-1-benzofuran-2-yl}ethyl)acetamide (32.3 mg, 0.100 mmol) obtained in Example 165 and 1-bromomethoxypropane (0.0306 mL, 0.200 mmol) and in the same manner as in Example 158, the title compound was obtained (10.5 mg, yield 27%) as a white solid.

Sources & evidence

ORD record
ord-db115f30d1404b59b789d1eb281cf9a9
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

Loading…