Bromocyclopentane → HCID 58047042, compound

HRID 1888781Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:24]=[CH:23][C:13]3[CH:14]=[C:15]([CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])[O:16][C:12]=3[CH:11]=2)=[CH:4][CH:3]=1.Br[CH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH:26]1([O:1][C:2]2[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]3[CH:24]=[CH:23][C:13]4[CH:14]=[C:15]([CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])[O:16][C:12]=4[CH:11]=3)=[CH:6][CH:7]=2)[CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

Reactant 2

HCID 8728Bromocyclopentane

HCID 58047041HCID 58047041, compound

Product 1

HCID 58047042HCID 58047042, compoundYield 25%

Procedure

Using N-(1-{6-[2-(4-hydroxyphenyl)ethyl]-1-benzofuran-2-yl}ethyl)acetamide (40.0 mg, 0.123 mmol) obtained in Example 165 and bromocyclopentane (0.147 mL, 1.85 mmol) and in the same manner as in Example 158, the title compound was obtained (11.9 mg, yield 25%) as a white solid.

Sources & evidence

ORD record: ord-b5b9dfd2ac2e437186829edf6c329529
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501804B2

Reaction notes

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