(Bromomethyl)cyclobutane → HCID 58047266, compound

HRID 1888784Notes

Reaction equation

HRID 1888784 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[CH:24]=[CH:23][C:13]3[CH:14]=[C:15]([CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])[O:16][C:12]=3[CH:11]=2)=[CH:4][CH:3]=1.Br[CH2:26][CH:27]1[CH2:30][CH2:29][CH2:28]1>>[CH:27]1([CH2:26][O:1][C:2]2[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]3[CH:24]=[CH:23][C:13]4[CH:14]=[C:15]([CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])[O:16][C:12]=4[CH:11]=3)=[CH:6][CH:7]=2)[CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 2734658(Bromomethyl)cyclobutaneHCID 58047041HCID 58047041, compound

Product 1

HCID 58047266HCID 58047266, compoundYield 70%

Procedure

Using N-(1-{6-[2-(4-hydroxyphenyl)ethyl]-1-benzofuran-2-yl}ethyl)acetamide (150 mg, 0.464 mmol) obtained in Example 165 and (bromomethyl)cyclobutane (0.155 mL, 1.39 mmol) and in the same manner as in Example 158, the title compound was obtained (127 mg, yield 70%) as a white solid.

Sources & evidence

ORD record
ord-b131c4c08db247198c65119bcf0bf95e
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

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