1-(6-Methylpyridazin-3-yl)methanamine → HCID 59432545, compound

HRID 1888924Notes

Reaction equation

HRID 1888924 reaction equation
[CH:1]([C:4]1[S:8][CH:7]=[N:6][C:5]=1[C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=2)[CH:17]=1)[C:12]([OH:14])=O)([CH3:3])[CH3:2].[CH3:25][C:26]1[N:31]=[N:30][C:29]([CH2:32][NH2:33])=[CH:28][CH:27]=1>>[CH:1]([C:4]1[S:8][CH:7]=[N:6][C:5]=1[C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=2)[CH:17]=1)[C:12]([NH:33][CH2:32][C:29]1[N:30]=[N:31][C:26]([CH3:25])=[CH:27][CH:28]=1)=[O:14])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 552845031-(6-Methylpyridazin-3-yl)methanamineHCID 59432544HCID 59432544, compound

Product 1

HCID 59432545HCID 59432545, compound

Procedure

3-(5-Isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid was reacted with C-(6-methyl-pyridazin-3-yl)-methylamine using the procedure of Example 2 to give 3-(5-isopropyl-thiazol-4-yl)-N-(6-methyl-pyridazin-3-ylmethyl)-5-(5-methyl-pyridin-2-yl)-benzamide, MS (M+H)=444.

Sources & evidence

ORD record
ord-5020809b27294a2d87a73d2b37421f51
Source dataset
uspto-grants-2013_08
Patent number
US08501933B2

Reaction notes

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