Sodium borohydride → N-(5-methyl-2-(3,4,5-trimethoxybenzylamino)phenyl)benzamide

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Reaction Steps

A suspension of compound (E)-N-(5-methyl-2-(3,4,5-trimethoxybenzylideneamino)phenyl)benzamide (3 mmol) in methanol was cooled with an ice bath. Sodium borohydride was added until the color turned white. Excess sodium borohydride was quenched by the addition of distilled water. The resulting mixture was extracted with ethyl acetate (50 mL×3). The combined organics were washed with brine, dried over anhydrous MgSO4, and concentrated in vacuum to obtain N-(5-methyl-2-(3,4,5-trimethoxybenzylamino)phenyl)benzamide as a solid.

Provenance & Evidence