反应详情

A suspension of compound (E)-N-(5-(pyrrolidin-1-yl)-2-(3,4,5-trimethoxybenzylideneamino)phenyl)benzamide (3 mmol) in methanol was cooled with an ice bath. Sodium borohydride was added until the color turned white. Excess sodium borohydride was quenched by the addition of distilled water. The resulting mixture was extracted with ethyl acetate (50 mL×3). The combined organics were washed with brine, dried over anhydrous MgSO4, and concentrated in vacuum to obtain N-(5-(pyrrolidin-1-yl)-2-(3,4,5-trimethoxybenzylamino)phenyl)benzamide as a solid.

1. temperaturewas cooled with an ice bath
2. customExcess sodium borohydride was quenched by the addition of distilled water
3. extractionThe resulting mixture was extracted with ethyl acetate (50 mL×3)
4. washThe combined organics were washed with brine
5. dry with materialdried over anhydrous MgSO4
6. concentrationconcentrated in vacuum