Acetone → HCID 54577999, compound

HRID 1888967Notes

Reaction equation

HRID 1888967 reaction equation
[CH2:1]1[C@@H:6]([C:7]#[N:8])[N:5]([C:9]([C@@H:11]([NH2:23])[C:12]23[CH2:21][C:19]4([OH:22])[CH2:20][CH:14]([CH2:15][CH:16]([CH2:18]4)[CH2:17]2)[CH2:13]3)=[O:10])[C@@H:4]2[C@H:2]1[CH2:3]2.[CH3:24][C:25]([CH3:27])=O>>[CH3:24][C:25](=[N:23][C@@H:11]([C:12]12[CH2:17][CH:16]3[CH2:15][CH:14]([CH2:20][C:19]([OH:22])([CH2:18]3)[CH2:21]1)[CH2:13]2)[C:9]([N:5]1[C@H:6]([C:7]#[N:8])[CH2:1][C@H:2]2[C@@H:4]1[CH2:3]2)=[O:10])[CH3:27]

Participants

3

Reactant 2

HCID 180AcetoneHCID 11243969Saxagliptin

Product 1

HCID 54577999HCID 54577999, compound

Procedure

Saxagliptine form H-1 (100 mg) was suspended in acetone (1 ml). The suspension was stirred for 24 hours at room temperature, after which it was filtered and dried on air, yielding 54 mg of crystalline product

Workup

  1. filtrationafter which it was filtered
  2. customdried on air

Sources & evidence

ORD record
ord-32f45f27aea24fecba19308497f41f11
Source dataset
uspto-grants-2013_08
Patent number
US08501960B2

Reaction notes

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