Saxagliptin Hydrate → Saxagliptin

HRID 1888970Notes

Reaction equation

HRID 1888970 reaction equation

[CH2:1]1[C@@H:6]([C:7]#[N:8])[N:5]([C:9]([C@@H:11]([NH2:23])[C:12]23[CH2:21][C:19]4([OH:22])[CH2:20][CH:14]([CH2:15][CH:16]([CH2:18]4)[CH2:17]2)[CH2:13]3)=[O:10])[C@@H:4]2[C@H:2]1[CH2:3]2.O>O>[CH2:1]1[C@@H:6]([C:7]#[N:8])[N:5]([C:9]([C@@H:11]([NH2:23])[C:12]23[CH2:21][C:19]4([OH:22])[CH2:20][CH:14]([CH2:15][CH:16]([CH2:18]4)[CH2:17]2)[CH2:13]3)=[O:10])[C@@H:4]2[C@H:2]1[CH2:3]2

Participants

3

Reactant 1

HCID 53297473Saxagliptin Hydrate

Product 1

HCID 11243969Saxagliptin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Saxagliptin monohydrate (300 mg) was dissolved in water (40 ml) and lyophilized yielding amorphous saxagliptin.

Sources & evidence

ORD record: ord-2f66d44e40bf480bb65e4313c5f72766
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501960B2

Reaction notes

Loading…