6-Fluoropyridine-2-carboxylic acid → 3,5-Difluoropicolinohydrazide

HRID 1888989Notes

Reaction equation

HRID 1888989 reaction equation
FC1N=C(C([NH:10][NH2:11])=O)C=CC=1.[F:12][C:13]1[C:14]([C:20]([OH:22])=O)=[N:15][CH:16]=[C:17]([F:19])[CH:18]=1.FC1N=C(C(O)=O)C=CC=1>>[F:12][C:13]1[C:14]([C:20]([NH:10][NH2:11])=[O:22])=[N:15][CH:16]=[C:17]([F:19])[CH:18]=1

Participants

4

Reactant 3

HCID 2260276-Fluoropyridine-2-carboxylic acidHCID 3458186-Fluoropyridine-2-carbohydrazideHCID 27832623,5-Difluoropyridine-2-carboxylic acid

Product 1

HCID 552809663,5-Difluoropicolinohydrazide

Procedure

3,5-Difluoro-2-pyridinecarbohydrazide was prepared in a manner analogous to that described above for 6-fluoro-2-pyridinecarbohydrazide (I23) but using 3,5-difluoro-2-pyridinecarboxylic acid (CAS [745784-04-7], commercially available e.g. from Matrix Scientific, Alfa Aesar or Apollo Scientific) in the place of 6-fluoro-2-pyridinecarboxylic acid.

Sources & evidence

ORD record
ord-662855e847264b56823da360bab49466
Source dataset
uspto-grants-2013_08
Patent number
US08501946B2

Reaction notes

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