Hydrochloric Acid → THIAZOLE-4-CARBOHYDRAZIDE

Participants

Reaction Steps

1,1-Dimethylethyl 2-(1,3-thiazol-4-ylcarbonyl)hydrazinecarboxylate (I64) (1.378 g, 5.66 mmol) was dissolved in 1,4-dioxane (15 mL) and to this was added 4M HCl in 1,4-dioxane (14.16 mL, 56.6 mmol). The solution was then stirred at room temperature for 18 hours. The solvent was then evaporated in vacuo and the remaining residue was loaded onto an SCX cartridge and washed with methanol before being eluted with 2M NH3 in DCM. The solution was then evaporated in vacuo to yield the product in 0.784 g.

Provenance & Evidence