反应详情

2,3-Dichloro-4-methylbenzoic acid (I70) (5.90 g, 26.2 mmol) and thionyl chloride (30 mL, 411 mmol) were heated at 85° C. for 4 hr in toluene (100 mL). The solvents were removed in vacuo and the residue was azeotroped with toluene (3×100 mL). The residue was used in subsequent steps without further purification assuming 100% yield. Compound not characterised at this step.

1. customThe solvents were removed in vacuo
2. customthe residue was azeotroped with toluene (3×100 mL)
3. customThe residue was used in subsequent steps without further purification