Hydrazine → 3-Hydroxypyridine-2-carbohydrazide

関与物質

反応手順

Hydrazine (0.248 mL, 7.91 mmol) was added under argon to a solution of methyl 3-hydroxy-2-pyridinecarboxylate (808 mg, 5.28 mmol) in ethanol (25 mL). The reaction mixture was stirred at reflux overnight (yellow solution). After cooling, a solid which has crashed out was filtrered to afford the desired product in 826 mg as a yellow solid.

情報源と証拠