反应详情

温度

80 °C

A mixture of 1,1-dimethylethyl 3-(aminocarbonyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate (I111) (0.2 g, 0.748 mmol) and Lawesson's reagent (0.151 g, 0.374 mmol) in benzene (7.48 ml) was heated at 80° C. for 2 h, left to stand over the weekend at RT and then heated for a further 6 h at 80° C. The mixture was cooled, concentrated and then chromatographed (0-5% MeOH in DCM) to give the desired product as a yellow solid in 99 mg.

1. waitleft
2. customto stand over the weekend at RT
3. temperatureheated for a further 6 h at 80° C
4. temperatureThe mixture was cooled
5. concentrationconcentrated
6. customchromatographed (0-5% MeOH in DCM)