Hydrochloric Acid → 5-Methyl-1,3-thiazole-2-carbohydrazide

Participants

Reaction Steps

A mixture of 1,1-dimethylethyl 2-[(5-methyl-1,3-thiazol-2-yl)carbonyl]hydrazinecarboxylate (I116)(451 mg, 1.753 mmol) in HCl (2.191 ml, 72.1 mmol) (4M solution in 1,4-dioxan) was stirred at room temperature under an atmosphere of argon for 18 hours. After this time, the solvent was removed under reduced pressure to give an off white coloured solid. The solid was dissovled in MeOH and passed through an SCX cartridge, washing first with MeOH and then with 2M NH3 in MeOH The NH3 containing fractions were combined and concentrated under reduced pressure to give a white coloured solid of desired product in 224 mg.

Provenance & Evidence