反应详情

A solution of ethyl amino(thioxo)acetate (500 mg, 3.75 mmol) in ethanol (9.387 ml) was stirred at room temperature under an atmosphere of argon. 1-Chloro-2-propanone (0.299 ml, 3.75 mmol) was added and the solution was heated to reflux for 48 hours. The solution was allowed to cool to room temperature and then it was concentrated under reduced pressure to give a yellow coloured oily solid. The residue was chromatographed [SiO2, 0-100% EtOAc in Hexane] to give a yellow coloured oil identified as product in 208 mg.

1. temperaturethe solution was heated
2. temperatureto reflux for 48 hours
3. concentrationit was concentrated under reduced pressure
4. customto give a yellow coloured oily solid
5. customThe residue was chromatographed [SiO2, 0-100% EtOAc in Hexane]
6. customto give a yellow coloured oil