HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → HCID 66599027, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 4-methyl-1,2-thiazole-3-carboxylate | HCID 66599351 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 66599027 | HCID 66599027 | — |
Reaction Steps
Methyl 4-methyl-3-isothiazolecarboxylate (I128) (57 mg, 0.363 mmol) was dissolved in methanol (3 mL), treated with hydrazine hydrate (0.027 mL, 0.544 mmol) then heated at reflux for 18 hours. Cooled to RT then solvent evaporated, azeotroped with Et2O (3 ml), and evaporated to afford a pale yellow solid of desired product in 57 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501946B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-69c0e7f40aae45c5ae2aee5ca03bb519 |
| Source note | uspto-grants-2013_08 |