3-(4-Pyridinyl)[1,2,4]triazolo[4,3-a]pyrazine → 3-(Pyridin-4-yl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrazine

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Reaction Steps

3-(4-Pyridinyl)[1,2,4]triazolo[4,3-a]pyrazine (538 mg, 2.73 mmol) was hydrogenated under atmospheric hydrogen with 10% Pd/C as a catalyst in ethanol at ambient temperature for 36 hours. The catalyst was filtered off and the solvent was evaporated. The residue was purified on silica gel chromatography using 0-20% of 2M methanol in ammonia—Dichloromethane as eluent to give 3-(4-pyridinyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine (0.288 g).

Provenance & Evidence