Water → 1-{[2-Chloro-3-(trifluoromethyl)phenyl]carbonyl}-5-(ethyloxy)-1,2,3,6-tetrahydropyrazine

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Reaction Steps

To a solution of 4-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-2-piperazinone (0.613 g, 2 mmol, e.g. as prepared in Intermediate 1) in Dichloromethane (5 ml) at room temperature was added triethyloxonium tetrafluoroborate (950 mg, 5.00 mmol). The reaction mixture was stirred for 18 hours. Dichloromethane (20 ml) and iced water (10 ml) were added and the pH was adjusted to pH 7 with solid sodium hydrogen carbonate. The organic phase was separated, washed with brine, dried and evaporated to give crude 1-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5-(ethyloxy)-1,2,3,6-tetrahydropyrazine which was used without further purification.

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