Benzoylhydrazine → 7-[(2-Chloro-4-fluorophenyl)carbonyl]-3-phenyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

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Reaction Steps

A mixture of 1-[(2-chloro-4-fluorophenyl)carbonyl]-5-(ethyloxy)-1,2,3,6-tetrahydropyrazine (0.228 g, 0.8 mmol, e.g. see preparation below) and benzohydrazide (benzoylhydrazine, 0.109 g, 0.800 mmol, CAS [613-94-5], commercially available e.g. from Sigma-Aldrich or ABCR) in 1-butanol (1 ml) was heated at reflux for 18 hours. After cooling to room temperature the solvent was evaporated and the residue was purified by mass-directed automated (preparative) HPLC (MDAP). A trituration with diethyl ether was then carried out to yield 7-[(2-chloro-4-fluorophenyl)carbonyl]-3-phenyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine (0.053 g).

Provenance & Evidence