反应详情

A mixture of 1-[(2,3-dichlorophenyl)carbonyl]-5-(ethyloxy)-1,2,3,6-tetrahydropyrazine (0.48 g, 1.594 mmol, e.g. prepared as described below) and 2-pyrazinecarbohydrazide (0.242 g, 1.753 mmol, CAS [768-05-8], commercially available e.g. from TimTec, J & W PharmLab or AKos Consulting) in anhydrous n-butanol (3.19 ml) was heated to reflux under argon atmosphere. After 2 hours the reaction was cooled to room temperature and concentrated in vacuo. The residue was purified by mass-directed automated (preparative) HPLC (MDAP) to give pure 7-[(2,3-dichlorophenyl)carbonyl]-3-(2-pyrazinyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine (0.260 g).

1. temperaturewas heated
2. temperatureto reflux under argon atmosphere
3. concentrationconcentrated in vacuo
4. customThe residue was purified