HCID 25133555, compound → HCID 25129100, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 11 (100 mg, 0.43 mmol) and 2nd generation Grubbs catalyst (18 mg, 0.02 mmol) in CH2Cl2 (10 mL) was heated to 45° C. for 1 h. After this time, the solvent was removed and the residue was purified by flash-chromatography (5:1 CHCl3/EtOAc) to afford 83 mg (94%) of 12 as a colourless oil: 1H NMR (CDCl3) δ 5.87-5.66 (m, 2H), 4.77-4.18 (m, 2H), 4.18-4.14 (m, 2H), 4.01-3.89 (m, 2H), 3.75-3.68 (m, 3H), 3.56-3.53 (m, 2H), 3.38 (s, 3H), 2.54-2.51 (m, 2H); 13C NMR (CDCl3) δ 130.6, 125.9, 94.3, 75.6, 75.1, 71.6, 70.3, 66.8, 58.9, 31.8.

Provenance & Evidence