HCID 25133899, compound → HCID 25129450, compound

Participants

Reaction Steps

A mixture of 22 (25 mg, 0.083 mmol) and a catalytic amount of 10% Pd/C in EtOAc (3 mL) was stirred at 23° C. under a hydrogen atmosphere. After 48 h the catalyst was filtered off and the filtrate was evaporated to afford 16 mg (92%) of 81 as a colorless oil: 1H NMR (CDCl3) δ 4.08-3.95 (m, 4H), 3.67 (dd, J=4.2, 9.9 Hz, 2H), 3.61-3.59 (m, 1H), 3.51 (dd, J=5.7, 9.9 Hz, 2H), 3.38-3.23 (m, 4H); 13C NMR (CDCl3) δ 69.0, 68.3, 64.5, 52.6.

Provenance & Evidence