Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 3-(N-Methylamino)-1-(2-thienyl)-1-propanol, (-)- | HCID 10095047 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 87623974 | HCID 87623974 | 63.1% |
Reaction Steps
A mixture of (S)-3-methylamino-1-thiophen-2-yl-propan-1-ol (5.0 g, 29.2 mmol), methylene to chloride (50 mL), p-toluenesulfonic acid hydrate (5.55 g, 29.2 mmol) and methanol (20 mL) is stirred 1 h at 25° C., then concentrated to dryness. The residue (10.8 g) which solidifies after a few hours is finally recrystallised from butanol (30 mL) affording a white powder (6.0 g, 60%);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08501967B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-8400a2f9c3d54c9c9fabcce00cd13486 |
|---|
| Source note | uspto-grants-2013_08 |
|---|
