HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Chloropropyl)dibutylamine → (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-dibutylaminopropoxy)phenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Chloropropyl)dibutylamine | HCID 96084 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | (2-Butyl-5-nitro-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone | HCID 11473234 | — |
| Reactant | (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone | HCID 22595055 | — |
| Product | (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-dibutylaminopropoxy)phenyl)methanone | HCID 10209258 | — |
Reaction Steps
Industrial application of this last reaction step involves difficulties, because 2-n-butyl-3-(4-methoxybenzoyl)-5-nitro-benzofuran (X) is mutagenic, and aluminum chloride is harmful for the health. The resulting 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitro-benzofuran (XI) on reaction with dibutylamino-propylchloride furnishes 2-n-butyl-3-[4-(3-dibutylamino-propoxy)benzoyl]-5-nitro-benzofuran (XII)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501971B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-4c3e52102a724d67b7057133efeb9934 |
| Source note | uspto-grants-2013_08 |