Lithium hydroxide, monohydrate → HCID 59610041, compound

Participants

Reaction Steps

To a solution of (2,4-difluoro-phenoxy)-[4-(tetrahydro-pyran-4-sulfonyl)-phenyl]-acetic acid methyl ester (0.35 g, 0.82 mmol) in THF (3 ml), was added lithium hydroxide monohydrate (0.035 g, 2.05 mmol) in 1 ml water and stirred overnight at room temperature. Solvent was removed under reduced pressure, residue obtained was taken into water (5 ml), extracted with diethyl ether (10 ml×2). Aqueous layer was acidified with 1 N HCl solution, and extracted with ethyl acetate (10 ml×3), washed with water and brine (20 ml, each) dried over anhydrous sodium sulfate, filtered and solvent was concentrated to provide (2,4-difluoro-phenoxy)-[4-(tetrahydro-pyran-4-sulfonyl)-phenyl]-acetic acid (0.28 gm).

Provenance & Evidence