Ethanol → 4-Mercapto-phenyl-acetic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-mercapto-phenyl acetic acid (5 gm, 29.72 mmol) in ethanol (60 ml) was added sulfuric acid (1.58 ml, 29.72 mmol) dropwise. Reaction mixture was then heated at 60° C. for 3 hr, concentrated to remove ethanol. The residue was neutralized with satd. aq. NaHCO3 solution and extracted with ethyl acetate (3×30 ml) washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to provide (4-mercapto-phenyl)-acetic acid ethyl ester (5.5 gm).

Provenance & Evidence