2-Aminothiazole → 2-(4-Cyclopropanesulfonylphenyl)-2-(2,4-difluoro-phenoxy)-N-thiazol-2-yl-acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	2-(4-Cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetic acid	HCID 59610032	—
Solvent	Dichloromethane	HCID 6344	—
Product	2-(4-Cyclopropanesulfonylphenyl)-2-(2,4-difluoro-phenoxy)-N-thiazol-2-yl-acetamide	HCID 25261986	—

Reaction Steps

Procedure-C: 2-(4-cyclopropanesulfonylphenyl)-2-(2,4-difluorophenoxy)acetic acid (1 equi) (obtained in step III) and HATU (1.5 equi) was dissolved in DCM. To this solution was added DIPEA (2 equi.) and stirred for 15 minutes followed by addition of 2-aminothiazole (1 equi.) and continued to stir over night at room temperature. Reaction mixture was diluted with dichloromethane, washed with water, brine, dried over anhydrous sodium sulfate, solvent was removed under reduced pressure to get the crude compound which was purified by flash chromatography to get the title product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08501955B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-1838805a072c416a955d4a4f68b3bf52
Source note	uspto-grants-2013_08