HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 56592266, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 59404902 | HCID 59404902 | — |
| Reactant | (4-Cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid | HCID 59610020 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 56592266 | HCID 56592266 | 33.3% |
Reaction Steps
The compound of example A76 was obtained by similar method described in example A75 using (4-Cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid (Preparation 14) (0.5 g, 1.47 mmol), 4-(2-Amino-thiazol-5-yloxy)-benzoicacid methyl ester (0.441 g, 1.76 mmol), HOBt (0.237 g, 1.76 mmol), and EDCI (0.337 g, 1.76 mmol), N-methyl morpholine (0.178 g, 1.76 mmom) in DMF (10 mL) to provide the title compound (280 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501955B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-d10e74bf0cfb40b79eea29ff9dd13400 |
| Source note | uspto-grants-2013_08 |