HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 56592267, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 59404902 | HCID 59404902 | — |
| Reactant | HCID 59610056 | HCID 59610056 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 56592267 | HCID 56592267 | 72% |
Reaction Steps
The compound of example A77 was obtained by similar method described in example A75 using (4-Cyclopropanesulfonyl-phenyl)-[(R)-(tetrahydro-furan-3-yl)oxy]-acetic acid (preparation 15) (0.150 g, 0.46 mmol), 4-(2-Amino-thiazol-5-yloxy)-benzoicacid methyl ester (0.140 g, 0.55 mmol), HOBt (0.075 g,0.55 mmol), and EDCI (0.106 g, 0.55 mmol), N-methyl morpholine (0.055 g, 0.55 mmom) in DMF (10 mL) to provide the title compound (185 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501955B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-945d72da50884cc9847c9c40cac00f97 |
| Source note | uspto-grants-2013_08 |