4-Methylmorpholine → HCID 56592345, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Methylmorpholine	HCID 7972	—
Reactant	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	[1,3]Thiazolo[5,4-b]pyridin-2-amine	HCID 592050	—
Reactant	(2,4-Difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid	HCID 59610025	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 56592345	HCID 56592345	119%

Reaction Steps

The compound of example A78 was obtained by similar method described in example A75 using (2,4-Difluoro-phenoxy)-[4-(piperidine-1-sulfonyl)-phenyl]-acetic acid (Preparation 2) (0.1 g, 0.27 mmol), thiazolo[5,4-b]pyridin-2-ylamine (0.042 g, 0.33 mmol), HOBt (0.044 g, 0.33 mmol), and EDCI (0.062 g, 0.33 mmol), N-methyl morpholine (0.034 g, 0.33 mmom) in DMF (10 mL) to provide the title compound (0.175 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08501955B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-235064ef6fe0469599caff6240e0fa30
Source note	uspto-grants-2013_08