4-Methylmorpholine → HCID 56592433, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Methylmorpholine	HCID 7972	—
Reactant	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	[1,3]Thiazolo[5,4-b]pyridin-2-amine	HCID 592050	—
Reactant	(4-Cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid	HCID 59610020	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 56592433	HCID 56592433	63.7%

Reaction Steps

The compound of example A79 was obtained by similar method described in example A75 using (4-cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid (Preparation 14) (0.2 g, 0.58 mmol), thiazolo[5,4-b]pyridin-2-ylamine (0.133 g, 0.88 mmol), HOBt (0.119 g, 0.88 mmol), and EDCI (0.168 g, 0.88 mmol), N-methyl morpholine (0.178 g, 0.88 mmol) in DMF (10 mL) to provide the title compound (0.175 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08501955B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-335e164c033647f1923d0bef3723a4a5
Source note	uspto-grants-2013_08