HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 59610057, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 45116259 | HCID 45116259 | — |
| Reactant | (4-Cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid | HCID 59610020 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59610057 | HCID 59610057 | 37.1% |
Reaction Steps
The compound of example A81 was obtained by similar method described in example A75 using (4-cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid (Preparation 14) (0.25 g, 0.73 mmol), 5-ethoxy-thiazolo[5,4-b]pyridin-2-ylamine (0.157 g, 0.80 mmol), HOBt (0.148 g, 1.10 mmol), and EDCI (0.210 g, 1.10 mmol), N-methyl morpholine (0.22, 2.20 mmol) in DMF (5 mL) to provide the title compound (0.140 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501955B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-d8ce342feee84026a5ff57ed09a6cd19 |
| Source note | uspto-grants-2013_08 |