HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 2-(4-Cyclopropanesulfonyl-phenyl)-N-(5-isopropoxy-thiazolo[5,4-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yloxy)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | (4-Cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid | HCID 59610020 | — |
| Reactant | 5-Isopropoxythiazolo[5,4-b]pyridin-2-amine | HCID 86648287 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Cyclopropanesulfonyl-phenyl)-N-(5-isopropoxy-thiazolo[5,4-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yloxy)-acetamide | HCID 59610059 | 38.9% |
Reaction Steps
The compound of example A82 was obtained by similar method described in example A75 using (4-cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid (Preparation 14) (0.100 g,0.29 mmol), 5-iso-propoxy-thiazolo[5,4-b]pyridin-2-ylamine (0.067 g, 0.32 mmol), HOBt (0.047 g, 0.35 mmol), and EDCI (0.067 g, 0.35 mmol), N-methyl morpholine (0.065 g, 0.58 mmol) in DMF (5 mL) to provide the title compound (0.060 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501955B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-0dc2c529a7eb4174a5dccc5df1012426 |
| Source note | uspto-grants-2013_08 |