Hydrochloric Acid → HCID 25262909, compound

Participants

Reaction Steps

{2-[2-(4-Cyclopropanesulfonylphenyl)-2-(4-fluorophenoxy)acetylamino]thiazol-4-yl}-acetic acid ethyl ester (obtained in example A54) was taken in THF, to it was added aqueous solution of LiOH and stirred for 1-4 h. After completion of the reaction, water and DCM was added and stirred for 5 min. The aqueous layer was acidified with 1 N HCl and extracted with ethyl acetate, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to get the title compound.

Provenance & Evidence