反应详情

温度

80 °C

To a suspension of sodium hydride (7.15 g, 179 mmol, 60% in oil) in DMSO (100 mL) was added tert-butyl cyanoacetate (24.8 g, 170 mmol) at 23° C. After the evolution of hydrogen ceased, 4-chloro-2-methylthiopyrimidine (13.7 g, 85 mmol) was added. The reaction was heated at 80° C. for 16 h. The reaction mixture was then cooled to room temperature and quenched with ice-cooled saturated ammonium chloride (300 mL). The solid was filtered and washed with water (2×200 mL). 300 mL of hexane was added to the solid and the suspension was heated at 60° C. for 1 h and then cooled to room temperature. The solid was filtered and washed with hexane to afford the title compound; 1H NMR 400 MHz (CDCl3) δ 7.82 (d, 1H), 6.74 (d, 1H), 2.63 (s, 3H), 2.61 (s, 1H), 1.52 (s, 9H); MS m/z: 266.0 (M+1).

1. temperatureThe reaction mixture was then cooled to room temperature
2. customquenched with ice-
3. temperaturecooled saturated ammonium chloride (300 mL)
4. filtrationThe solid was filtered
5. washwashed with water (2×200 mL)
6. addition300 mL of hexane was added to the solid
7. temperaturethe suspension was heated at 60° C. for 1 h
8. temperaturecooled to room temperature
9. filtrationThe solid was filtered
10. washwashed with hexane