Hydrochloric Acid → N-[[4-Bromo-1-[2-(4-fluorophenoxy)ethoxy]-2-naphthalenyl]carbonyl]-2-methylalanine

Participants

Reaction Steps

61 mg 2-({4-bromo-1-[2-(4-fluoro-phenoxy)-ethoxy]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid methyl ester in 0.5 ml THF, 0.36 ml of 2 M sodium hydroxide and 1.7 ml methanol were reacted in a microwave at 120° C. for 6 min. The reaction was then acidified with 2 M hydrochloric acid and extracted with ethyl acetate twice. The combined organic layers were dried over magnesium sulphate, and concentrated. After purification of the residue by RP-HPLC 27 mg of 2-({4-bromo-1-[2-(4-fluoro-phenoxy)-ethoxy]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid were obtained.

Provenance & Evidence