Cesium carbonate → HCID 68842094, compound

Participants

Reaction Steps

To 5.2 g cesium carbonate and 1.6 g methyl 1-hydroxy-2-naphthoate in 10 ml abs. DMF was added 1.9 g (2-bromethoxy)-tert.butyldimethylsilane and the mixture was reacted for 4 h at 60-80° C. The reaction was poured unto ice and extracted with ethyl acetate twice. The combined organic layers were washed with aqueous sat. sodium hydrogen carbonate solution and brine, dried over magnesium sulphate and concentrated in vacuo to yield 2.7 g of 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-naphthalene-2-carboxylic acid methyl ester.

Provenance & Evidence