Tetrabutylammonium Fluoride → HCID 68842699, compound

Participants

Reaction Conditions

Reaction Steps

To 112 mg 2-({1-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid methyl ester in 1 ml abs. THF at −10° C. 0.25 ml tetra-butylammonium fluoride (1 M in THF) was added, and the reaction was stirred at 0° C. for 3 h. It was then poured onto ice-water and extracted with ethyl acetate three times. The combined organic layers were then washed with water, dried over sodium sulphate, concentrated in vacuo and crystallized from n-pentane to yield 67 mg 2-{[1-(2-hydroxy-ethoxy)-naphthalene-2-carbonyl]-amino}-2-methyl-propionic acid methyl ester.

Provenance & Evidence