HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 2-({1-[2-(3,5-Difluoro-phenoxy)-ethoxy]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3,5-Difluorophenol | HCID 75928 | — |
| Reactant | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| Reactant | HCID 68842699 | HCID 68842699 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-({1-[2-(3,5-Difluoro-phenoxy)-ethoxy]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid methyl ester | HCID 68840887 | — |
Reaction Steps
To a solution of 67 mg 2-{[1-(2-hydroxy-ethoxy)-naphthalene-2-carbonyl]-amino}-2-methyl-propionic acid methyl ester and 29 mg 3,5-difluorophenol in 1 ml THF at 0° C. 58 mg triphenyl phosphine and 46 μl diisopropylazodicarboxylate were added. After 16 h at room temperature the reaction was concentrated in vacuo and after chromatography on silica (ethyl acetate/heptane) 80 mg 2-({1-[2-(3,5-difluoro-phenoxy)-ethoxy]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid methyl ester were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501981B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-fd7fb4e629dc44fbb153746d1b9c6462 |
| Source note | uspto-grants-2013_08 |